Features of impaired seminiferous tubule differentiation are associated with germ cell neoplasia in adult men surgically treated in childhood because of cryptorchidism.

Seminiferous tubule differentiation was related to the occurrence of germ cell neoplasia in 38 men, aged 17-47, treated surgically in childhood for cryptorchidism.Tissues from 46 testes obtained from biopsies taken as a neoplastic preventive procedure or whole testes removed because of GCT were evaluated quantitatively.Paraffin sections were treate

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Beyond Dependency: Economic Development, Capacity Building, and Generational Sustainability for Indigenous People in Canada

Indigenous people in Canada have continuously been marginalized in economic participation due to an Bobble Head unequal relationship with the state.Many First Nations communities are looking to engage and be a part of the economy while overcoming this dependency.This article explores this unequal relationship and expands on how we can engage Bottle

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Differential expression and function of PDE8 and PDE4 in effector T cells: Implications for PDE8 as a drug target in inflammation.

Abolishing the inhibitory signal of intracellular cAMP is a prerequisite for effector T (Teff) cell function.The regulation of cAMP within leukocytes critically depends on its degradation by cyclic nucleotide phosphodiesterases (PDEs).We have previously shown that PDE8A, a PDE isoform with 40-100-fold greater affinity for cAMP than PDE4, is selecti

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